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How to Work With Us
Submit Requirements
Provide your site dimensions, required ISO class, and industry-specific needs (GMP, ESD, etc.) to our experts.
Custom Technical Proposal
Receive a detailed design proposal within 24 hours, including airflow strategies, material lists, and transparent pricing.
Modular Production
We manufacture your modular panels, HVAC units, and FFUs with strict QC to ensure full compliance with ISO 14644 standards.
Global Shipping & Setup
Fast global logistics followed by onsite installation guidance and performance validation to get you operational quickly.
Specifications & Models
Containment & Airflow
A Negative Pressure Hardwall Cleanroom uses a controlled pressure cascade and inward airflow to help contain airborne particles within the designated area. Each system is configured according to the process, material hazards, room layout, and applicable regulatory requirements.
Negative Pressure Control
Pressure Differential: Typically −10 to −20 Pa relative to adjacent areas, subject to risk assessment and project requirements.
Pressure Cascade: Air moves from cleaner adjacent spaces toward the contained room to reduce the outward migration of airborne contaminants.
Air Balance: Exhaust airflow is maintained above supply airflow to create stable negative pressure under normal operating conditions.
Airflow & Filtration
Supply Air: H13 or H14 HEPA filtration can be selected according to the required ISO cleanliness class and qualification criteria.
Airflow Pattern: Diffusers and return or exhaust points are positioned to support effective room sweeping and minimize stagnant zones.
Exhaust Treatment: Dedicated exhaust systems may include HEPA filtration, safe-change housings, or bag-in/bag-out filters based on the identified hazard.
Safety & Monitoring
Continuous Monitoring: Differential-pressure sensors provide real-time room status and can connect to a BMS or EMS for data recording.
Alarm Functions: Visual and audible alarms notify operators when pressure moves outside the approved operating range.
HVAC Interlocks: Supply and exhaust systems can be interlocked to help prevent loss or reversal of the intended pressure relationship.
Sealed Enclosure: Hardwall panels, doors, windows, joints, and service penetrations are sealed to support stable pressure and controlled leakage.
Design & Verification
Final airflow volume, air-change rate, pressure setpoint, filter grade, and exhaust treatment are established through a project-specific risk assessment. Performance can be verified through airflow measurement, differential-pressure testing, HEPA integrity testing, particle counting, alarm checks, and airflow-visualization studies in accordance with the agreed qualification scope and applicable ISO 14644 requirements.
Important: HEPA filters capture particles but do not remove every gas or chemical vapor. Processes involving VOCs, corrosive gases, toxic vapors, or highly potent materials may require activated carbon, scrubbers, safe-change filtration, or other engineered controls. Final containment design should be reviewed by qualified professionals using material hazard data, occupational exposure limits, and local regulations.
Process Configurations
For powder weighing, sampling and dispensing, the cleanroom can be configured with inward directional airflow, dedicated exhaust and local extraction at emission points. Airlocks and controlled transfer devices may be added to reduce particle migration. Final containment measures should be based on material toxicity, dust generation, batch quantity and occupational exposure limits.
Laboratory configurations can support sample preparation, analytical testing and controlled research involving potentially hazardous materials. Depending on the process risk, the room may incorporate personnel airlocks, pass-through boxes and continuous pressure monitoring while operating alongside suitable fume hoods, biosafety cabinets or other primary containment equipment.
Chemical handling areas can be designed with dedicated exhaust, inward airflow and source-capture ventilation. HEPA filtration is intended for particulate control and does not remove most gases or vapors. Processes involving VOCs, corrosive gases or toxic vapors may require activated carbon, wet scrubbers or other treatment selected by a qualified ventilation engineer.
Higher-risk pharmaceutical or toxic compounds may require multiple pressure zones, closed processing equipment and safe-change exhaust filters. Bag-in/bag-out housings, segregated waste routes and decontamination provisions can be incorporated where justified by the containment assessment. Room-level negative pressure should not ｒｅｐｌａｃｅ primary containment for highly potent materials.
Supply and exhaust air volumes are balanced to create controlled airflow from adjacent areas toward the contained room. Typical room pressure differentials may range from −10 to −20 Pa, but setpoints are project-specific. Airlock arrangements, door-opening effects and system recovery should be evaluated before the operating pressure cascade is approved.
A dedicated exhaust system can be configured with H13 or H14 HEPA filtration, duty and standby fans, airflow monitoring and safe filter-change provisions. Filter type, discharge location and exhaust treatment should be determined by the contaminant, process quantity, environmental requirements and applicable local regulations rather than cleanliness classification alone.
Personnel airlocks, material airlocks, pass-through boxes and defined waste exits can be arranged to support the required containment strategy. Door interlocks and operating procedures help limit simultaneous openings and pressure disruption. The final layout should separate clean, contaminated and waste movement wherever the process risk assessment requires it.
Monitoring options may include differential pressure, airflow, fan status, filter condition, temperature and relative humidity, with configurable alarms and HVAC interlocks. Commissioning and qualification can include particle counting, HEPA integrity testing, airflow measurement, pressure verification, smoke visualization and recovery testing in accordance with the project specification and applicable ISO 14644 methods.
Engineering Notice: Negative-pressure containment is a risk-based engineering strategy. The appropriate cleanliness class, pressure differential, airflow arrangement, exhaust treatment and transfer controls must be determined from the specific process, contaminant properties, occupational exposure limits, equipment loads and applicable regulations. Cleanroom classification alone does not demonstrate containment performance.
Validation & Delivery
Pharmaceutical Powder Handling
Requirement: Weighing, dispensing and sampling may release airborne powders that must be contained.
Configuration: Negative-pressure airlocks, dedicated filtered exhaust and local extraction can limit particle migration. Final controls depend on material hazards, exposure limits and process quantities.
Laboratory Sample Processing
Requirement: Sample preparation and testing may require controlled inward airflow to protect adjacent areas.
Configuration: Interlocked doors, pass boxes, pressure monitoring and dedicated exhaust can be integrated. Room airflow should complement any required fume hood or biosafety cabinet.
Chemical & VOC Operations
Requirement: Chemical processes may generate particles, gases or vapors requiring safe capture and discharge.
Configuration: Dedicated exhaust, source capture and suitable duct materials may be used. HEPA filters control particles; VOCs may require activated carbon, scrubbers or other treatment.
Potent Compound Containment
Requirement: Highly active materials require controls for exposure, cleaning, maintenance and waste removal.
Configuration: Multi-stage pressure zones, bag-in/bag-out filters and controlled transfer routes may be included. Higher-risk processes may also require isolators or closed equipment.
Supply and exhaust air are balanced to maintain inward airflow. Typical pressure differentials are −10 to −20 Pa, subject to project design and verification.
Exhaust systems may include H13 or H14 HEPA filters, safe-change housings and standby fans according to the identified process hazard.
Personnel airlocks, pass boxes and waste routes help reduce conflicting traffic and preserve the required pressure relationship.
Pressure sensors, alarms and HVAC interlocks support safe operation. Testing may include pressure, airflow, HEPA integrity and particle counting.
Engineering notice: Final specifications must be based on material hazards, exposure limits, process conditions and local regulations. HEPA filtration controls particles but does not remove most gases or VOCs.
FAQ
A Negative Pressure Hardwall Cleanroom is designed to maintain inward airflow and help contain airborne particles, powders or other process contaminants. It is commonly used for pharmaceutical processing, laboratory work, hazardous-material handling and other applications where protecting adjacent areas is a primary requirement. The final containment strategy should be determined by a documented process and risk assessment.
Deiiang Negative Pressure Hardwall Cleanrooms can be configured for ISO Class 5 to ISO Class 8 under ISO 14644-1, depending on the process, occupancy, equipment load, airflow design and filtration system. The required class is confirmed during project design and verified by particle-count testing after installation.
Negative pressure is maintained by controlling the balance between supply and exhaust airflow so that air moves from adjacent cleaner areas into the room. A typical room pressure differential is approximately −10 to −20 Pa, although the specified value depends on the application and risk assessment. Differential-pressure sensors, local displays, alarms and supply–exhaust interlocks can be provided for continuous monitoring.
Supply air can be filtered through H13 or H14 HEPA filters selected according to the required cleanliness level. The dedicated exhaust system can include HEPA filtration, bag-in/bag-out housings, safe-change arrangements or other hazard-specific treatment options. Exhaust air should not be recirculated unless a qualified risk assessment and applicable regulations permit it.
Handover documentation can include as-built drawings, operating manuals, calibrated-instrument certificates and relevant material or equipment records. Qualification testing may include airborne particle counts to ISO 14644-1, HEPA filter integrity testing, airflow-volume measurements, room differential-pressure verification, temperature and humidity checks, recovery testing and airflow-visualization studies, as required by the project specification.
Deiiang can provide preventive-maintenance guidance, replacement pre-filters and HEPA filters, pressure and airflow inspections, alarm-function checks and support for periodic cleanroom requalification. Maintenance frequency is established according to operating conditions, contamination risks, filter loading, applicable standards and the facility’s quality-management procedures.
Learn More About Deiiang Hardwall Cleanrooms
- Video
- Data Sheet
- Certificates & Gallery
- Quality Control
- After-Sales Service
Ventilation Times (ACH)
| ISO Class | ACH (Air Changes Per Hour) |
|---|---|
| ISO 3 | 360 - 540 |
| ISO 4 | 300 - 540 |
| ISO 5 | 240 - 480 |
| ISO 6 | 50 - 60 |
| ISO 7 | 30 - 40 |
| ISO 8 | 15 - 25 |
CE Certificate for Deiiang Air Shower and HEPA Filters
Electromagnetic Compatibility EMC Certification
Filter CE-Certification
Deiiang Hardwall Cleanrooms Quality Control Flowchart
