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Cleanroom Air Changes Per Hour (ACH): 

By Deiiang™ Cleanroom Solutions | Product Designer: Jason.peng

What is Cleanroom Air Changes Per Hour (ACH)?

Cleanroom Air Changes Per Hour (ACH), also known as the air exchange rate, is a critical metric that quantifies how often the entire volume of air within a cleanroom is replaced with newly filtered and conditioned air every hour. It's calculated by dividing the total volume of air supplied to the cleanroom per hour (often measured in cubic feet per hour or cubic meters per hour) by the total cubic volume of the cleanroom itself. This rate is a direct indicator of the cleanroom's ventilation system efficiency in refreshing its internal atmosphere.

The significance of ACH in cleanrooms stems from its direct impact on contamination control. By facilitating a continuous and rapid exchange of air, a high ACH rate ensures that airborne particulate matter, microorganisms, and other pollutants are effectively diluted and removed from the environment. This constant replenishment of clean air is fundamental to maintaining the stringent ISO cleanliness classifications required for sensitive manufacturing, research, and healthcare processes, thereby protecting product integrity, equipment, and personnel from contamination.

ISO Cleanroom Classifications & ACH Requirements

ISO ClassAir Changes Per Hour (ACH)Typical Applications
ISO 5 (Class 100)240-480Pharmaceutical manufacturing, aseptic processing
ISO 6 (Class 1,000)150-240Medical device manufacturing
ISO 7 (Class 10,000)60-90Vaccine production, electronics assembly
ISO 8 (Class 100,000)20-40Plastic molding, food processing

Key Factors Influencing Cleanroom ACH Requirements

Multiple variables impact the optimal Air Changes Per Hour for any given Cleanroom application. Understanding these factors enables more precise system design and operational control.

Personnel Density

Each person generates 100,000-1,000,000 particles/minute, increasing required ACH

Process Contamination

Manufacturing operations may require 15-30% higher Air Changes Per Hour

Room Configuration

Complex layouts may require customized ACH calculations for different zones

Equipment Load

Heat-generating equipment affects airflow patterns and ACH effectiveness

Proper assessment of these variables ensures appropriate Air Changes Per Hour specification. Deiiang™ engineering analysis typically identifies 3-5 key factors that significantly influence ACH requirements in any given application.

Risks of Improper ACH: Understanding the Consequences

Both insufficient and excessive Air Changes Per Hour levels present significant risks to cleanroom operations. Understanding these risks informs proper system design and operational protocols.

Insufficient ACH Risks

  • Particle accumulation exceeding ISO classification limits
  • Increased product contamination and reduced yield
  • Regulatory non-compliance and audit failures
  • Cross-contamination between processes or products

Excessive ACH Risks

  • Unnecessary energy consumption (30-60% higher costs)
  • Increased filter replacement frequency and maintenance
  • Potential airflow turbulence disrupting contamination control
  • Reduced equipment lifespan due to constant high operation

Regular assessment of Air Changes Per Hour performance helps identify and mitigate these risks. Jason.peng emphasizes that proper ACH validation should occur during commissioning and at regular intervals throughout the facility lifecycle.

Frequently Asked Questions (FAQ)

How does high ACH contribute to contamination control in cleanrooms?

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What factors influence the required ACH in a cleanroom?

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What are typical ACH rates for different cleanroom classifications?

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WHow do you calculate ACH for a room?

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Why is ACH so important in a cleanroom?

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What is Air Changes Per Hour (ACH)?

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