How to ensure the safety of clean rooms

Author:Jason Peng
Cleanroom Engineering Technology Manager of Deiiang Company.

Product R&D Manager of GDC Inc. Cleanroom Equipment Manufacturing Company.

Executive Director of Guangdong Cleanroom Industry Association of China.

Engaged in R&D of related products for 15 years, with rich relevant technical experience
2024-11-06 | Visits:

Cleanroom technology of the Future

Shaping a Safer, Purer World

The safety of modular clean rooms is the key to ensuring the quality of laboratory environment and the health of staff. Effective clean room safety management includes the safety of building structures, biosafety, circuit system safety and fire protection system safety.

Machine & Electrical Safety | RS

Clean Room Building Structure Safety

Structural material selection
Building Materials should comply with international standards (ISO 14644). Stainless steel and fire-retardant coatings improve corrosion resistance and prevent contamination.
Isolation and ventilation design
Requires air change rate of ≥20 times/hour to control particulate concentration and reduce cross-contamination risks.
Sealing test
Regular air tightness tests maintain environmental stability and prevent air leakage.

Biosafety

Microbial control

Regular monitoring ensures <100 bacteria/m³ air (WHO standards).

Biosafety cabinets

Must comply with BS EN 12469 for biological sample handling.

PPE Requirements

Proper PPE reduces infection risk by >90% during sample handling.

Safety Area	Key Standard	Critical Requirement
Circuit System	IEC 60601	Annual electrical safety assessments
Fire Protection	NFPA 101	1 extinguisher/100m² + evacuation drills
Static Control	ANSI/ESD S20.20	Grounding for all equipment (prevents 30% ESD damage)

Fire Protection System Safety

Fire alarm systems must comply with NFPA standards for rapid emergency response
Extinguisher placement requires minimum 1 unit per 100m² based on risk assessment
Evacuation plans must be regularly drilled with all staff familiar with routes

Integrated Safety Approach

Ensuring clean room safety requires comprehensive management of building structure, biosafety, electrical systems, and fire protection. Through adherence to international standards, regular inspections, and effective protocols, clean rooms can operate safely and efficiently, providing reliable environments for scientific research and production.