How to Design Industry-Specific Cleanrooms

By Jason Peng, Lead Engineer at Deiiang™ Cleanroom Solutions

Introduction

Cleanrooms are the invisible guardians of modern industries, from life-saving vaccines to cutting-edge microchips. But designing one isn’t a "one-size-fits-all" game. As a specialist with 12 years of experience at **GCC®️ Cleanroom Systems**, I’ll decode how top industries meet their unique contamination control challenges—with hard data, international standards, and proven solutions. Let’s dive in!

Pharmaceutical Cleanrooms: Where Precision Saves Lives

Governed by EU GMP Annex 1 and ISO 14644-5, pharmA CleanRooms demand surgical precision:

ISO Class 5 (Grade A/B) Zones: ≤3,520 particles/m³ (≥0.5µm) for vial filling.

Environmental Controls:

Temperature: 20–24°C (±0.5°C variance).

Humidity: 45–55% RH (±3% tolerance).

Pressure cascade: ≥15 Pa differentials between zones.

Real-World Case: A Deiiang™  client reduced cross-contamination by 90% using GCC®️ double HEPA ceiling modules (0.3µm filtration @ 99.995% efficiency).

Electronics Manufacturing: Battling Invisible Killers

Per IEST-RP-CC012, static control is non-negotiable:

Class 100 (ISO 5) Cleanrooms:

Particle count: ≤100 particles/ft³ (≥0.5µm).

Humidity: 45%±3% RH to prevent ESD (electrostatic discharge).

 Critical Tools:

Deii®️ ionizing blowers (neutralizes ±2,000V in <3 sec).

GCC®️ conductive epoxy floors (surface resistance: 10⁶–10⁹ Ω).

*Cost-Saving Tip*: A 10% humidity deviation can spike defect rates by 25%—always use Deiiang™ PLC-controlled HVAC systems.

Food Production: Microbial Defense at Scale

Aligned with ISO 22000 and FDA 21 CFR Part 117

 SC-Certified Requirements:

HEPA filters (99.97% @ 0.3µm) + 20–30 air changes/hour.

Stainless steel surfaces (Ra ≤0.8µm roughness) to resist biofilm.

Deii®️ Pro Tip: Slope floors at 1.5%–2% (1 cm rise per 60 cm run) to prevent stagnant water—a key audit failure point.

Hospital Operating Theaters: Airflow Saves Lives

Meeting iso 14644-1 Class 5 and ASHRAE 170

Unidirectional Flow: 0.25–0.35 m/s velocity over surgical sites.

Emergency Protocols

N+1 redundancy for HVAC systems (tested every 15 days).

FM-200 gas fire suppression (zero residue).

*GCC®️ Project Highlight*: A hospital achieved 50% energy savings using our laminar flow diffusers with 40% airflow uniformity.

Laboratories: Precision Meets Safety

Biosafety Labs (BSL-2/3)

Negative pressure (-10 Pa to -15 Pa).

Deii®️ Class II biosafety cabinets (0.45 m/s inflow velocity).

Vibration Control

 Limit floor vibration to <2 µm/s² (per **VC-G** criteria).

GCC®️ pneumatic isolators reduce equipment vibration by 85%.

3 Golden Rules for Cleanroom Success

1. Zoning Strategy: Use GCC®️ modular panels to create ISO Class 5–8 zones—a client saved 35% by avoiding over-specification.

2. Automation First: Deiiang™ PLC systems cut human error by 60% in pressure monitoring.

3. Validation Matters: Always test per ISO 14644-3(particle counts) and EN 1822(filter leaks).

About the Author

Jason Peng is a certified Cleanroom designer at Deiiang™, part of the GCC®️ Group. With 450+ projects across 12 countries, his team specializes in turnkey cleanrooms compliant with ISO, GMP, and SEMI standards.

*Contact: jason.peng@deiiang.com | GCC®️ Cleanroom Systems © 2024*