• Items are placed inside the VHP PassBox chamber.

• Vaporized Hydrogen Peroxide (VHP) is introduced into the chamber for decontamination.

• VHP sterilizes surfaces by penetrating and eliminating microorganisms.

• After the decontamination cycle, the vapor is neutralized.

• The items are then safely transferred into the cleanroom or sterile area.

• Support stand or Base box

• Door release buttons

• Interlock release rocker switches

• Buzzer system (to alert personnel on the opposite side during material transfer)

• Intercom system

• Fan fault alarms with customized blowers

• Lead shielding

• Roller Conveyors (only for DFLH)

• Auto sliding PVC doors (only for DFLH)

• Rails to hang gowns (only for DFLH)

1. How does VHP passbox decontamination affect the environment?

VHP passbox decontamination has a minimal environmental impact as the Vaporized Hydrogen Peroxide (VHP) breaks down into harmless byproducts—water vapor and oxygen—after the sterilization process. Unlike some chemical sterilants, VHP does not leave harmful residues, making it an eco-friendly option. Proper disposal of any residual chemicals is required, but VHP is generally considered safe for the environment when used correctly.

2. What types of contaminants can a VHP passbox remove from items?

A VHP passbox is effective in removing a wide range of contaminants, including:

• Bacteria

• Viruses

• Fungi

• Spore-forming organisms

These contaminants are eliminated by the action of Vaporized Hydrogen Peroxide (VHP), which effectively sterilizes items before they are transferred into a cleanroom or controlled environment.

3. How do you ensure proper airflow in a VHP passbox?

Ensuring proper airflow in a VHP passbox involves regular maintenance of the ventilation and filtration systems. The passbox should be equipped with HEPA filters to remove particulates from the air and maintain optimal airflow. It is also important to check for any blockages in the air ducts and ensure that pressure differentials are properly maintained to prevent contamination.

4. How is VHP passbox used in pharmaceutical manufacturing?

In pharmaceutical manufacturing, VHP passboxes are used to sterilize materials before they enter cleanrooms or areas with stringent contamination control. The VHP process eliminates harmful microorganisms from packaging, equipment, and raw materials, ensuring that only sterile items are introduced into the sterile production areas. This helps maintain product integrity and compliance with regulatory standards.

5. What is the lifespan of a VHP passbox?

The lifespan of a VHP passbox generally ranges from 10 to 15 years, depending on the quality of the materials and how well it is maintained. Regular cleaning, filter replacement, and calibration of sterilization cycles can extend the passbox's service life. It's important to inspect the passbox periodically to ensure it remains effective and free from wear and tear.

6. How do you clean the interior of a VHP passbox?

Cleaning the interior of a VHP passbox involves wiping down surfaces with an appropriate disinfectant, ensuring that no residue is left behind. After the decontamination cycle, it's important to remove any particles or debris from the passbox’s interior. For more thorough cleaning, a detailed inspection should be performed to check for any areas that may need extra attention, such as seals or filtration systems.

7. What is the cost of a VHP passbox?

The cost of a VHP passbox varies depending on factors like size, features, and customization options. On average, prices range from \$5,000 to \$15,000. Custom features, such as integration with cleanroom systems or added safety features, may increase the price. It’s important to select a passbox that meets the specific needs of your cleanroom while also fitting within your budget.

8. What are the safety precautions when using a VHP passbox?

When using a VHP passbox, safety precautions include:

• Ensuring proper ventilation to avoid the buildup of hydrogen peroxide vapors.

• Wearing appropriate personal protective equipment (PPE), such as gloves and goggles, when handling the passbox.

• Checking the integrity of seals to prevent vapor leakage.

These precautions help prevent accidents and ensure the safe operation of the passbox during the decontamination process.

9. How long does it take for a VHP passbox to decontaminate items?

The time it takes for a VHP passbox to decontaminate items typically ranges from 30 minutes to 1 hour, depending on factors such as the size of the items, the concentration of vapor, and the level of contamination. A complete sterilization cycle involves several phases, including vaporization, exposure, and neutralization, ensuring that all surfaces are properly decontaminated.

10. Can a VHP passbox be used in high-containment laboratories?

Yes, VHP passboxes are commonly used in high-containment laboratories. These laboratories require strict contamination control to protect both workers and research materials. The VHP passbox ensures that materials entering the laboratory are free from contaminants, maintaining the integrity of the lab’s sterile environment and preventing cross-contamination.

11. Can VHP passboxes be used to transfer chemicals safely between cleanrooms?

Yes, VHP passboxes can be used to transfer chemicals safely between cleanrooms. The passbox sterilizes containers and surfaces to prevent the introduction of harmful contaminants when chemicals are transferred. However, the chemicals being transferred must be compatible with the VHP process to avoid damage or reaction with the vaporized hydrogen peroxide.

12. What is VHP in a VHP passbox?

VHP stands for Vaporized Hydrogen Peroxide. It is a sterilizing agent used in VHP passboxes to eliminate microorganisms from surfaces and air. The hydrogen peroxide is vaporized and introduced into the passbox to effectively decontaminate materials before they are transferred into sterile environments like cleanrooms.

13. How does a VHP passbox improve safety in cleanroom operations?

A VHP passbox improves safety in cleanroom operations by ensuring that any materials entering the cleanroom are sterilized beforehand. By using vaporized hydrogen peroxide, it effectively eliminates bacteria, viruses, and other harmful contaminants, preventing the introduction of pathogens into the sterile environment. This helps maintain the safety of both the products and the personnel in the cleanroom.

14. How do you maintain a VHP passbox?

Maintaining a VHP passbox involves regular inspection and cleaning of its components. Key tasks include:

• Checking seals and gaskets for wear and replacing them as needed.

• Cleaning the interior surfaces to prevent contamination build-up.

• Replacing filters and ensuring that the sterilization cycle is functioning properly.

Following a regular maintenance schedule ensures that the passbox remains effective and operates safely.

15. Can VHP passboxes be used for electronic equipment?

Yes, VHP passboxes can be used for electronic equipment, but it is important to ensure that the electronic components are not damaged by the vaporized hydrogen peroxide. Some passboxes are specifically designed with features that protect sensitive electronic equipment, such as controlled humidity and temperature, to avoid damaging delicate circuits during the decontamination process.

16. How do you optimize the efficiency of a VHP passbox?

To optimize the efficiency of a VHP passbox, it is important to maintain the correct cycle parameters, including vapor concentration and exposure time. Regular checks of the sealing mechanisms and air filtration systems ensure that there are no leaks or blockages. Additionally, ensuring that the passbox is compatible with the cleanroom’s airflow and pressure systems will help maximize its sterilization effectiveness.