• Items are placed inside the VHP PassBox chamber.

• Vaporized Hydrogen Peroxide (VHP) is introduced into the chamber for decontamination.

• VHP sterilizes surfaces by penetrating and eliminating microorganisms.

• After the decontamination cycle, the vapor is neutralized.

• The items are then safely transferred into the cleanroom or sterile area.

• Support stand or Base box

• Door release buttons

• Interlock release rocker switches

• Buzzer system (to alert personnel on the opposite side during material transfer)

• Intercom system

• Fan fault alarms with customized blowers

• Lead shielding

• Roller Conveyors (only for DFLH)

• Auto sliding PVC doors (only for DFLH)

• Rails to hang gowns (only for DFLH)

1. How do you ensure proper airflow in a VHP passbox?

To ensure proper airflow in a VHP passbox, it is important to regularly check the ventilation system to ensure it is not obstructed. The passbox should have a well-designed airflow system that maintains the correct pressure differential between the cleanroom and the passbox. This ensures that any contaminants in the passbox are not released into the cleanroom when the passbox doors are opened.

2. How do you optimize the efficiency of a VHP passbox?

Optimizing the efficiency of a VHP passbox involves several key steps:

• Regular maintenance of the VHP generator to ensure consistent vapor distribution.

• Ensuring proper sealing of the passbox to prevent leakage during decontamination cycles.

• Adjusting the cycle time based on the type and size of the items being decontaminated.

By following these practices, you can maximize the sterilization effectiveness of the VHP passbox and maintain cleanroom integrity.

3. Are VHP passboxes compliant with FDA regulations?

Yes, VHP passboxes are designed to meet FDA regulations, especially in industries like pharmaceuticals and medical device manufacturing. They are essential for maintaining sterility and preventing contamination in critical environments. The use of vaporized hydrogen peroxide for decontamination aligns with FDA standards for sterilization in controlled environments.

4. What is VHP in a VHP passbox?

VHP stands for Vaporized Hydrogen Peroxide, which is the sterilizing agent used in VHP passboxes. This vaporized form of hydrogen peroxide is highly effective at killing bacteria, viruses, and fungi, making it ideal for decontaminating materials before they enter sterile environments like cleanrooms or laboratories.

5. What type of filter is used in a cleanroom VHP passbox?

In a cleanroom VHP passbox, a high-efficiency particulate air (HEPA) filter is typically used. This filter captures and removes airborne particles, ensuring that the air inside the passbox remains free from contaminants. It also helps maintain the sterile conditions required in cleanrooms by preventing the entry of particulate matter.

6. What are the environmental impacts of using VHP in a passbox?

The environmental impacts of using VHP in a passbox are relatively minimal when the system is properly maintained. VHP is a non-toxic and environmentally friendly sterilizing agent, as it decomposes into water vapor and oxygen after the decontamination cycle. However, improper disposal or excessive use can contribute to chemical waste, so proper handling and neutralization are essential.

7. How do you integrate a VHP passbox into a cleanroom system?

Integrating a VHP passbox into a cleanroom system involves placing the passbox at an appropriate entry point where it can effectively decontaminate materials before they enter the controlled environment. It should be connected to the cleanroom's air circulation and filtration systems, ensuring that the pressure differential is maintained and that no contaminants are transferred into the cleanroom during the decontamination process.

8. How does a cleanroom VHP passbox work?

A cleanroom VHP passbox works by introducing vaporized hydrogen peroxide into the chamber, which is then absorbed by the items placed inside. The vaporized hydrogen peroxide penetrates the surfaces, eliminating harmful microorganisms. After the decontamination process, the vapor is neutralized, allowing for safe transfer of items into the cleanroom or other sterile environments.

9. What industries use VHP passboxes the most?

VHP passboxes are most commonly used in industries that require stringent contamination control, such as:

• Pharmaceuticals

• Biotechnology

• Medical devices

• Food processing

These industries rely on VHP passboxes to maintain sterile conditions and prevent cross-contamination of sensitive materials.

10. Can a VHP passbox be used for both sterilizing and transferring items?

Yes, a VHP passbox can be used for both sterilizing and transferring items. The passbox serves as a decontamination chamber that ensures any materials being transferred into a cleanroom are sterile. After the sterilization process, the materials can be safely moved into the cleanroom environment without compromising its controlled conditions.

11. How does VHP passbox decontamination affect the items inside?

VHP passbox decontamination affects items by eliminating microorganisms from their surfaces. The vaporized hydrogen peroxide penetrates all areas, including cracks and crevices, ensuring thorough sterilization. However, the VHP process is gentle on most materials and does not damage the items, making it ideal for sensitive equipment and products.

12. What is the typical lifespan of the VHP solution in a passbox?

The typical lifespan of the VHP solution used in a passbox depends on usage and maintenance. Generally, the VHP solution can be used for several cycles before needing to be replaced. It is important to regularly monitor the effectiveness of the solution to ensure proper sterilization and replace it as necessary to maintain decontamination efficiency.

13. What is the lifespan of a VHP passbox?

The lifespan of a VHP passbox varies based on usage, maintenance, and the quality of the materials used. With proper care, a VHP passbox can last for many years, often exceeding 10 years of service. Regular inspections, cleaning, and component replacements help prolong its functionality and ensure it continues to meet sterilization requirements.

14. How does VHP passbox decontamination differ from UV decontamination?

VHP passbox decontamination differs from UV decontamination in its method of sterilization. While VHP uses vaporized hydrogen peroxide to penetrate surfaces and kill microorganisms, UV decontamination relies on ultraviolet light to disrupt the DNA of microbes. VHP is more effective at reaching deep into cracks and crevices, while UV is typically limited to surface sterilization.

15. How do you adjust the VHP passbox settings for different types of materials?

Adjusting the VHP passbox settings for different types of materials involves changing parameters like cycle time, VHP concentration, and humidity levels. More delicate materials may require shorter cycles with lower concentrations, while more robust materials can withstand longer decontamination cycles. It is important to refer to the manufacturer's guidelines and conduct trials to determine the optimal settings for various materials.