• Items are placed inside the VHP PassBox chamber.

• Vaporized Hydrogen Peroxide (VHP) is introduced into the chamber for decontamination.

• VHP sterilizes surfaces by penetrating and eliminating microorganisms.

• After the decontamination cycle, the vapor is neutralized.

• The items are then safely transferred into the cleanroom or sterile area.

• Support stand or Base box

• Door release buttons

• Interlock release rocker switches

• Buzzer system (to alert personnel on the opposite side during material transfer)

• Intercom system

• Fan fault alarms with customized blowers

• Lead shielding

• Roller Conveyors (only for DFLH)

• Auto sliding PVC doors (only for DFLH)

• Rails to hang gowns (only for DFLH)

1. How does a VHP passbox improve safety in cleanroom operations?

A VHP passbox improves safety in cleanroom operations by ensuring that any materials entering the cleanroom are decontaminated before they are introduced into the sterile environment. The use of Vaporized Hydrogen Peroxide (VHP) ensures that bacteria, viruses, and other pathogens are eliminated, maintaining a sterile and safe environment for operations. This is crucial for protecting both the products being manufactured and the health of those working in the cleanroom.

2. What is the cost of a VHP passbox?

The cost of a VHP passbox can vary based on its size, features, and customization options. Typically, the price range for a standard VHP passbox is between \$5,000 and \$15,000. Factors such as additional safety features, integrated sensors, and compatibility with specific cleanroom systems can influence the final cost.

3. Can VHP passboxes be customized for specific cleanroom needs?

Yes, VHP passboxes can be customized to meet the specific needs of different cleanroom environments. Customization options may include:

• Size adjustments to accommodate larger or specialized items.

• Enhanced sealing and filtration for more stringent cleanroom standards.

• Integration with existing cleanroom air handling systems.

These customizations ensure that the passbox effectively supports the unique requirements of the cleanroom and the materials being processed.

4. Can VHP passboxes be used for electronic equipment?

Yes, VHP passboxes can be used for electronic equipment, but care must be taken when selecting the appropriate passbox. The VHP sterilization process is effective at decontaminating most surfaces, but electronic components can be sensitive to the high humidity and vapor involved. Some passboxes are specifically designed to be safe for electronic equipment, ensuring that sterilization does not damage the devices.

5. Can VHP passboxes be used for sensitive electronic equipment?

VHP passboxes can be used for sensitive electronic equipment, but extra precautions should be taken to avoid damaging the equipment during the sterilization process. Specialized passboxes with controlled humidity and temperature settings can prevent moisture buildup, ensuring that sensitive components like circuit boards are not affected by the vaporized hydrogen peroxide.

6. How do you test the effectiveness of a VHP passbox?

The effectiveness of a VHP passbox is typically tested through the use of biological indicators and chemical indicators. These indicators confirm that the sterilization process was successful by showing whether microorganisms have been eliminated. Additionally, air or surface sampling may be done to check for any residual contamination following the decontamination cycle.

7. How do VHP passboxes meet ISO standards for cleanrooms?

VHP passboxes are designed to meet ISO standards for cleanrooms by ensuring that they provide thorough decontamination without compromising the integrity of the cleanroom environment. The passbox is equipped with effective sealing, filtration, and airflow systems that comply with the necessary requirements for contamination control, as outlined in ISO 14644-1 standards. These features help maintain cleanroom classification and sterility levels.

8. Can a VHP passbox be used in a controlled contamination environment (CCE)?

Yes, VHP passboxes can be used in controlled contamination environments (CCE), where strict contamination control is required. The passbox helps to eliminate microorganisms from materials before they are transferred into the CCE, reducing the risk of contamination. This is particularly important in industries such as biotechnology, pharmaceuticals, and healthcare, where contamination control is critical.

9. How do you optimize the efficiency of a VHP passbox?

To optimize the efficiency of a VHP passbox, ensure that the sterilization cycle is properly calibrated according to the material type and contamination level. Regular maintenance, such as cleaning the interior surfaces and checking the integrity of seals and filters, is essential for optimal performance. Additionally, ensuring that the passbox is compatible with the cleanroom’s air circulation and pressure systems will improve its overall efficiency.

10. How do you confirm the proper functioning of a VHP passbox?

The proper functioning of a VHP passbox can be confirmed through routine checks such as verifying the decontamination cycle’s parameters (e.g., vapor concentration and exposure time), inspecting seals and filters for wear and tear, and conducting microbial tests on materials after sterilization. Regular maintenance and calibration checks are crucial to ensure the passbox continues to perform effectively.

11. Can a VHP passbox be used for airlocks between different cleanroom zones?

Yes, a VHP passbox can be used as an airlock between different cleanroom zones. It helps to prevent contamination when transferring materials between zones with different cleanliness classifications. By sterilizing materials before they move from one area to another, the passbox ensures that contamination risks are minimized and cleanroom standards are maintained.

12. Can a VHP passbox be used in high-containment laboratories?

Yes, VHP passboxes are suitable for use in high-containment laboratories, where maintaining sterility and controlling contamination is critical. The passbox provides a safe and effective means of decontaminating materials before they enter or exit high-containment areas. This helps to protect both the materials being handled and the laboratory environment from contamination.

13. What are the benefits of using a VHP passbox in cleanrooms?

Using a VHP passbox in cleanrooms offers several benefits, including:

• Ensuring the decontamination of materials before they enter sterile areas.

• Maintaining the integrity of the cleanroom environment by preventing cross-contamination.

• Reducing the risk of microbial contamination in sensitive environments.

These benefits are critical in industries such as pharmaceuticals, biotechnology, and healthcare, where sterility is paramount.

14. How do you perform routine checks on a VHP passbox?

Routine checks on a VHP passbox involve verifying that all components are functioning properly. This includes inspecting seals, filters, and the vapor generation system. Regular calibration of the VHP cycle parameters (such as exposure time and vapor concentration) is also necessary to ensure the sterilization process is effective. Additionally, cleaning and sanitizing the interior of the passbox should be done regularly to prevent contamination.

15. What is a VHP passbox?

A VHP passbox is a sterilization device used to decontaminate materials before they are introduced into cleanrooms or other controlled environments. It utilizes Vaporized Hydrogen Peroxide (VHP) to eliminate microorganisms, ensuring that only sterile materials are transferred into sensitive areas. This helps maintain the integrity and sterility of the cleanroom environment.

16. What is the lifespan of a VHP passbox?

The lifespan of a VHP passbox depends on several factors, including the quality of the materials used, the frequency of use, and the maintenance practices followed. With proper maintenance, a VHP passbox can last for 10 to 15 years. Regular inspections, filter replacements, and sealing checks are essential to extend the lifespan and maintain optimal performance.