• Items are placed inside the VHP PassBox chamber.

• Vaporized Hydrogen Peroxide (VHP) is introduced into the chamber for decontamination.

• VHP sterilizes surfaces by penetrating and eliminating microorganisms.

• After the decontamination cycle, the vapor is neutralized.

• The items are then safely transferred into the cleanroom or sterile area.

• Support stand or Base box

• Door release buttons

• Interlock release rocker switches

• Buzzer system (to alert personnel on the opposite side during material transfer)

• Intercom system

• Fan fault alarms with customized blowers

• Lead shielding

• Roller Conveyors (only for DFLH)

• Auto sliding PVC doors (only for DFLH)

• Rails to hang gowns (only for DFLH)

1. What are the installation requirements for a cleanroom VHP passbox?

Installing a cleanroom VHP passbox requires careful consideration of several factors. It should be placed at a point where it can effectively transfer materials in and out of the cleanroom without disrupting airflow or cleanliness. The installation requires proper ventilation and an adequate power supply for the VHP generator. Additionally, the passbox should be tightly sealed to prevent leaks of vaporized hydrogen peroxide.

2. What types of materials should not be placed in a VHP passbox?

Certain materials should not be placed in a VHP passbox, including:

• Heat-sensitive items that may be damaged by the VHP process

• Items made of porous materials that may absorb hydrogen peroxide

• Electronic components that are not resistant to the sterilizing process

These materials can be adversely affected by the decontamination process and may not be suitable for use in a VHP passbox.

3. What are the typical sizes of a cleanroom VHP passbox?

The typical sizes of a cleanroom VHP passbox can vary based on the specific needs of the cleanroom. Common internal dimensions range from smaller units with dimensions around 19.6" x 19.6" x 19.6" for smaller items, to larger units that may accommodate larger equipment or bulk materials. The size of the passbox should be selected based on the volume of materials being processed and the available space within the cleanroom.

4. Can VHP passboxes be used for electronic equipment?

VHP passboxes can be used for electronic equipment, but it is essential to ensure that the equipment is resistant to the effects of vaporized hydrogen peroxide. Special precautions may be necessary for sensitive electronics, such as ensuring that they are properly sealed or using a more controlled cycle to prevent any potential damage to the components.

5. What are the maintenance requirements for a VHP passbox?

Regular maintenance is crucial for ensuring the optimal performance of a VHP passbox. Key maintenance tasks include:

• Cleaning the passbox interior to prevent buildup of contaminants.

• Inspecting the VHP generator and filters for proper function.

• Replacing the hydrogen peroxide solution as needed.

Following a routine maintenance schedule ensures that the passbox continues to function effectively and meets the required sterility standards.

6. How do you integrate a VHP passbox into a cleanroom system?

To integrate a VHP passbox into a cleanroom system, it should be positioned in a location that allows easy access for transferring materials while maintaining cleanroom integrity. The passbox should be connected to the cleanroom's air filtration system and have proper seals to prevent contamination. Integration also includes ensuring that the passbox works in tandem with the cleanroom's pressure differential and airflow requirements.

7. How do you optimize the efficiency of a VHP passbox?

To optimize the efficiency of a VHP passbox, ensure that:

• The passbox is regularly calibrated to ensure correct VHP concentration and vapor distribution.

• The decontamination cycle is adjusted based on the load size and material type.

• The passbox is well-maintained, including regular cleaning and proper sealing to prevent leaks.

By following these practices, the VHP passbox will maintain its sterilizing effectiveness and efficiency over time.

8. How do you troubleshoot issues with a VHP passbox?

Troubleshooting issues with a VHP passbox involves checking for common problems such as improper sealing, low hydrogen peroxide concentration, or equipment malfunction. Start by inspecting the passbox for any visible damage or leaks. Verify that the VHP generator is working correctly and that the filters are not clogged. If problems persist, consult the manufacturer's manual for diagnostic steps or contact technical support.

9. How is the VHP passbox related to contamination control in aseptic environments?

The VHP passbox plays a critical role in contamination control within aseptic environments by ensuring that materials and equipment entering the cleanroom are sterilized. The vaporized hydrogen peroxide used in the passbox kills bacteria, viruses, and fungi, which helps maintain the integrity of the aseptic environment. This process reduces the risk of cross-contamination and ensures that sterile conditions are upheld in critical areas.

10. What is VHP in a VHP passbox?

VHP stands for Vaporized Hydrogen Peroxide, which is used as the sterilizing agent in a VHP passbox. VHP is a highly effective disinfectant that can eliminate a wide range of microorganisms, including bacteria, viruses, and fungi. It is an ideal choice for cleanroom applications because it can effectively sterilize surfaces without leaving harmful residues behind.

11. What materials are VHP passboxes made from?

VHP passboxes are typically made from stainless steel, which is known for its durability, ease of cleaning, and resistance to corrosion. Stainless steel is also non-reactive to the hydrogen peroxide vapor, making it an ideal material for the construction of passboxes that are exposed to harsh sterilizing agents.

12. How do VHP passboxes handle hazardous materials?

VHP passboxes are designed to handle hazardous materials in a safe and controlled manner. The passbox uses a closed system for vaporizing hydrogen peroxide and contains the vapor within the chamber during the sterilization process. This ensures that hazardous materials are effectively decontaminated before being transferred into a cleanroom, while minimizing exposure to harmful substances.

13. How do VHP passboxes help with contamination control?

VHP passboxes help with contamination control by using vaporized hydrogen peroxide to decontaminate materials before they enter a cleanroom or sterile environment. This ensures that any microorganisms, bacteria, or viruses present on the surfaces of the materials are eliminated, preventing contamination and preserving the sterile conditions of the cleanroom.

14. How do you ensure proper airflow in a VHP passbox?

To ensure proper airflow in a VHP passbox, it is important to regularly check the ventilation system and make sure there are no blockages. The passbox should be equipped with an effective air filtration system, including HEPA filters, to maintain a clean environment. The airflow should create a pressure differential to prevent contaminants from entering the cleanroom when the passbox doors are opened.

15. How do you test the effectiveness of a VHP passbox?

Testing the effectiveness of a VHP passbox involves verifying that the sterilization process has been completed successfully. This can be done through biological indicators or chemical indicators that change color after exposure to the vaporized hydrogen peroxide. Additionally, air samples or surface swabs can be tested for contamination to confirm that the decontamination cycle was effective.

16. What is the difference between a VHP passbox and a standard passbox?

The main difference between a VHP passbox and a standard passbox is the sterilization method. A VHP passbox uses vaporized hydrogen peroxide to decontaminate materials, whereas a standard passbox typically relies on air pressure differentials or simple physical barriers to prevent contamination. The VHP method provides a more thorough and effective sterilization process, especially in high-risk environments.

17. How does VHP passbox decontamination compare to other methods?

VHP passbox decontamination is more effective compared to other methods such as UV or chemical sprays because it can penetrate deeper into materials, including hard-to-reach surfaces. Additionally, VHP does not leave harmful residues behind, unlike some chemicals, making it ideal for cleanroom applications. It also offers faster and more consistent decontamination than UV light, which is limited to surface sterilization.

18. What is the difference between hydrogen peroxide and VHP in passboxes?

The main difference between hydrogen peroxide and VHP in passboxes is the form of hydrogen peroxide used. VHP is the vaporized version of hydrogen peroxide, which allows it to permeate surfaces more effectively than liquid hydrogen peroxide. This vaporized form ensures a more thorough and consistent sterilization process in environments where contamination control is critical.