• Items are placed inside the VHP PassBox chamber.

• Vaporized Hydrogen Peroxide (VHP) is introduced into the chamber for decontamination.

• VHP sterilizes surfaces by penetrating and eliminating microorganisms.

• After the decontamination cycle, the vapor is neutralized.

• The items are then safely transferred into the cleanroom or sterile area.

• Support stand or Base box

• Door release buttons

• Interlock release rocker switches

• Buzzer system (to alert personnel on the opposite side during material transfer)

• Intercom system

• Fan fault alarms with customized blowers

• Lead shielding

• Roller Conveyors (only for DFLH)

• Auto sliding PVC doors (only for DFLH)

• Rails to hang gowns (only for DFLH)

1. Can VHP passboxes be used in pharmaceutical environments?

Yes, VHP passboxes are commonly used in pharmaceutical environments due to their ability to provide effective sterilization before materials are introduced into sterile areas. The use of vaporized hydrogen peroxide ensures that microorganisms, bacteria, and viruses are eliminated, maintaining the sterility of pharmaceutical products and ensuring compliance with stringent regulatory standards.

2. How do you test the effectiveness of a VHP passbox?

Testing the effectiveness of a VHP passbox is typically done through biological and chemical indicators. These indicators change color or show growth when exposed to the vaporized hydrogen peroxide, confirming whether the decontamination process was successful. Additionally, surface samples or air quality tests can be conducted to check for residual contamination after a cycle.

3. How can I prevent cross-contamination using a VHP passbox?

To prevent cross-contamination using a VHP passbox, it’s important to:

• Ensure proper sealing during the decontamination cycle to prevent leakage.

• Clean and disinfect the passbox regularly to remove any potential contaminants.

• Properly handle materials to avoid introducing contamination when transferring them in and out of the passbox.

By following these steps, you can reduce the risk of cross-contamination and maintain a sterile environment in controlled settings.

4. What is VHP in a VHP passbox?

VHP stands for Vaporized Hydrogen Peroxide. It is a sterilizing agent used in VHP passboxes to decontaminate materials before they enter sterile environments. The vaporized form of hydrogen peroxide is highly effective in killing microorganisms, such as bacteria and viruses, making it an ideal choice for cleanroom sterilization processes.

5. How do you properly dispose of VHP chemicals used in passboxes?

Proper disposal of VHP chemicals used in passboxes is essential for environmental safety. Typically, after use, the hydrogen peroxide breaks down into harmless byproducts—water and oxygen—so it does not pose a significant hazard. However, any residual chemical should be neutralized using a neutralizing agent before disposal to ensure no harmful levels of hydrogen peroxide remain. Follow local regulations and safety protocols for disposal to minimize any environmental impact.

6. What are the benefits of using a VHP passbox in cleanrooms?

The benefits of using a VHP passbox in cleanrooms include:

• Ensuring thorough decontamination of materials before they enter sterile environments.

• Minimizing the risk of contamination by killing microorganisms on surfaces.

• Maintaining the integrity of controlled environments by preventing the introduction of harmful contaminants.

These benefits make VHP passboxes essential in industries such as pharmaceuticals, biotechnology, and food processing, where maintaining sterility is crucial.

7. What is a VHP passbox?

A VHP passbox is a sterilization chamber used to decontaminate materials before they enter a cleanroom or other controlled environments. It utilizes Vaporized Hydrogen Peroxide (VHP) to eliminate bacteria, viruses, and fungi from surfaces, ensuring that only sterile materials are transferred into sterile areas. This process helps prevent contamination and maintain a sterile environment.

8. What are the typical sizes of a cleanroom VHP passbox?

The typical sizes of a cleanroom VHP passbox vary depending on the intended use and the materials to be sterilized. Common dimensions include units that measure 24.5" x 24.5" x 24.5", but larger or smaller passboxes can be customized to fit specific needs. The size should be chosen based on the volume of materials to be processed and the available space in the cleanroom.

9. Can a VHP passbox be used for both sterilizing and transferring items?

Yes, a VHP passbox can be used for both sterilizing and transferring items. The passbox effectively decontaminates materials using vaporized hydrogen peroxide before they are transferred into a cleanroom or other sterile areas. Once the sterilization cycle is complete, the items can be safely moved without compromising the sterility of the environment.

10. What features should I look for in a high-quality VHP passbox?

When choosing a high-quality VHP passbox, look for features such as:

• Effective sealing to prevent vapor leakage during the sterilization process.

• Durability and resistance to corrosion, often made from stainless steel.

• Compatibility with the cleanroom’s air filtration and pressure systems.

These features ensure that the passbox performs effectively and maintains a sterile environment for critical materials.

11. What is the importance of using a VHP passbox in controlled environments?

Using a VHP passbox in controlled environments is crucial for maintaining the sterility of sensitive materials. It prevents contamination by sterilizing items before they enter sterile areas, ensuring that microorganisms and pathogens are eliminated. This helps preserve the integrity of controlled environments in industries such as pharmaceuticals, biotechnology, and healthcare.

12. What type of filter is used in a cleanroom VHP passbox?

In a cleanroom VHP passbox, a HEPA (High-Efficiency Particulate Air) filter is typically used. This filter is designed to capture airborne particles, ensuring that the air inside the passbox remains free from contaminants during the sterilization process. HEPA filters are critical in maintaining cleanroom standards by preventing the introduction of particles into sensitive environments.

13. How do you ensure proper airflow in a VHP passbox?

To ensure proper airflow in a VHP passbox, regularly check the air circulation system for blockages or malfunctions. The passbox should be equipped with an effective air filtration system and maintain the correct pressure differential to prevent contaminants from entering the cleanroom when the doors are opened. Routine maintenance and system checks are essential for maintaining proper airflow.

14. What is the process of decontaminating a cleanroom passbox using VHP?

The decontamination process in a cleanroom VHP passbox involves introducing vaporized hydrogen peroxide into the chamber, where it penetrates surfaces to eliminate microorganisms. After a set period, the vapor is neutralized, leaving only water vapor and oxygen as byproducts. The sterilized materials are then ready to be safely transferred into the cleanroom.

15. Can VHP passboxes be used for food processing facilities?

Yes, VHP passboxes can be used in food processing facilities to ensure that materials entering sterile environments are free of contaminants. The VHP process is highly effective at eliminating bacteria, viruses, and fungi, making it ideal for food safety applications where contamination control is paramount. However, it is important to ensure that the passbox and the VHP solution used are compatible with food processing standards.

16. What is the air exchange rate in a VHP passbox?

The air exchange rate in a VHP passbox refers to how often the air in the passbox is replaced during the decontamination cycle. Typically, this rate is adjusted to ensure optimal vapor distribution and sterilization efficiency. The exchange rate is critical for maintaining uniformity of the vaporized hydrogen peroxide throughout the passbox during the sterilization process.

17. How does VHP passbox decontamination compare to other methods?

VHP passbox decontamination is more effective than many other sterilization methods because it can penetrate hard-to-reach surfaces, cracks, and crevices, ensuring thorough sterilization. Unlike UV light, which only disinfects surfaces, VHP can sterilize both surfaces and the air within the passbox. It also does not leave residues behind, unlike some chemical sterilants, making it an ideal choice for cleanroom environments.